Infections and Infectious Diseases

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A Phase 1 Study to Evaluate Safety, Tolerability, and PK of TBI-223 in Healthy Adults

Conditions:   Tuberculosis;   Tuberculosis, Pulmonary
Interventions:   Drug: TBI-223 50mg;   Drug: Placebo for TBI-223 50mg;   Drug: TBI-223 100, 300, 600, 1200, 1400 mg;   Drug: Placebo for TBI-223 100, 300, 600, 1200, 1400 mg
Sponsor:   Global Alliance for TB Drug Development
Recruiting
ClinicalTrials.gov: Infections_Infectious_Diseases | Recruiting, Not yet recruiting, Available Studies | United States | First posted in the last 100 days

February 22, 2019 / by / in
Poor Sleep and Inflammation in HIV-Infected Adults

Conditions:   HIV-1-infection;   Sleep Deprivation;   Inflammation
Intervention:   Behavioral: Sleep deprivation
Sponsors:   University of Pittsburgh;   National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting
ClinicalTrials.gov: Infections_Infectious_Diseases | Recruiting, Not yet recruiting, Available Studies | United States | First posted in the last 100 days

February 21, 2019 / by / in
Mucosal and Systemic Immunity After Viral Challenge of Healthy Volunteers Vaccinated With Inactivated Influenza Vaccine Via the Intranasal Versus Intramuscular Route

Condition:   Influenza
Interventions:   Biological: Flucelvax Quadrivalent inactivated influenza vaccine;   Other: A/Bethesda/MM2/H1N1 Passage 6 virus
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting
ClinicalTrials.gov: Infections_Infectious_Diseases | Recruiting, Not yet recruiting, Available Studies | United States | First posted in the last 100 days

February 19, 2019 / by / in
Study to Assess Safety and Ability to Induce Immune Responses of HIV-1 Vaccines M3 and M4 Given Alone or in Combination in HIV-infected Adults

Condition:   HIV-1 Infection
Interventions:   Biological: MVA.tHIVconsv3;   Biological: MVA.tHIVconsv4;   Other: Placebo
Sponsors:   University of North Carolina, Chapel Hill;   National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting
ClinicalTrials.gov: Infections_Infectious_Diseases | Recruiting, Not yet recruiting, Available Studies | United States | First posted in the last 100 days

February 18, 2019 / by / in
Placement of Antibiotic Powder in Wounds During the Emergency Room

Condition:   Open Fracture
Intervention:   Drug: Vancomycin
Sponsors:   The University of Texas Health Science Center at San Antonio;   United States Army Institute of Surgical Research;   San Antonio Military Medical Center
Not yet recruiting
ClinicalTrials.gov: Infections_Infectious_Diseases | Recruiting, Not yet recruiting, Available Studies | United States | First posted in the last 100 days

February 16, 2019 / by / in
Experimental Human Infection With Neisseria Gonorrhoeae

Condition:   Gonococcal Infection
Interventions:   Drug: Cefixime;   Drug: Ceftriaxone;   Drug: Ciprofloxacin;   Biological: Neisseria gonorrhoeae strain FA1090 A26;   Biological: Neisseria gonorrhoeae strain FA7537
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting
ClinicalTrials.gov: Infections_Infectious_Diseases | Recruiting, Not yet recruiting, Available Studies | United States | First posted in the last 100 days

February 15, 2019 / by / in
Study to Evaluate the Effect of GSK3640254 on the Pharmacokinetics of Tenofovir Alafenamide/Emtricitabine

Condition:   HIV Infections
Interventions:   Drug: Tenofovir alafenamide/emtricitabine;   Drug: GSK3640254
Sponsor:   ViiV Healthcare
Not yet recruiting
ClinicalTrials.gov: Infections_Infectious_Diseases | Recruiting, Not yet recruiting, Available Studies | United States | First posted in the last 100 days

February 14, 2019 / by / in
Combining TLR9 Agonist With bNAbs for Reservoir Reduction and Immunological Control of HIV

Condition:   HIV-1-infection
Interventions:   Drug: Saline;   Drug: Lefitolimod;   Drug: 3BNC117 and 10-1074
Sponsors:   University of Aarhus;   Aalborg Universitetshospital;   Odense University Hospital;   Rigshospitalet, Denmark;   Hvidovre University Hospital;   The Peter Doherty Institute for Infection and Immunity;   University of Utah
Not yet recruiting
ClinicalTrials.gov: Infections_Infectious_Diseases | Recruiting, Not yet recruiting, Available Studies | United States | First posted in the last 100 days

February 13, 2019 / by / in