Genetic Disease

A Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-based Treatment Combinations in Patients With Locally Advanced or Metastatic Urothelial Carcinoma After Failure With Platinum-Containing Chemotherapy

Condition:   Urothelial Carcinoma
Interventions:   Drug: Atezolizumab;   Drug: Enfortumab Vedotin;   Drug: Niraparib;   Drug: Hu5F9-G4;   Drug: Isatuximab;   Drug: Linagliptin;   Drug: Tocilizumab
Sponsors:   Hoffmann-La Roche;   Forty Seven Inc.,Tesaro Inc., Seattle Genetics and Astellas, Sanofi
Not yet recruiting
ClinicalTrials.gov: Genetic_Disease | Recruiting, Not yet recruiting, Available Studies | United States | First posted in the last 100 days

March 24, 2019 / by / in
Identification of Biomarkers in Spinocerebellar Ataxia 3

Condition:   Spinocerebellar Ataxia Type 3
Intervention:   Other: Specimen Collection
Sponsors:   University of Michigan;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting
ClinicalTrials.gov: Genetic_Disease | Recruiting, Not yet recruiting, Available Studies | United States | First posted in the last 100 days

March 22, 2019 / by / in
A SAD/MAD to Assess the Safety, Pharmacokinetics and Pharmacodynamics of FT-4202 in Healthy Volunteers and Sickle Cell Disease Patients

Conditions:   Healthy Volunteers;   Sickle Cell Disease
Interventions:   Drug: FT-4202/Placebo;   Drug: FT-4202
Sponsors:   Forma Therapeutics, Inc.;   Medpace, Inc.
Recruiting
ClinicalTrials.gov: Genetic_Disease | Recruiting, Not yet recruiting, Available Studies | United States | First posted in the last 100 days

March 19, 2019 / by / in
Lead-in Study to Collect Prospective Efficacy and Safety Data of Current FVIII Prophylaxis Replacement Therapy in Adult Hemophilia A Participants

Conditions:   Blood Coagulation Disorder;   Blood Coagulation Disorders, Inherited;   Coagulation Protein Disorders;   Hemophilia A;   Genetic Diseases, Inborn;   Genetic Diseases, X-Linked;   Hematologic Diseases;   Hemorrhagic Disorders;   Factor VIII Deficiency
Intervention:   Drug: Standard of Care FVIII Replacement therapy
Sponsor:   Spark Therapeutics
Recruiting
ClinicalTrials.gov: Genetic_Disease | Recruiting, Not yet recruiting, Available Studies | United States | First posted in the last 100 days

March 17, 2019 / by / in
A Study to Determine Frequency of DNA-repair Defects in Men With Metastatic Prostate Cancer

Condition:   Metastatic Prostate Cancer
Intervention:   Other: Saliva, Blood, or Existing Tissue Sample Collection and Analysis
Sponsor:   Janssen Research & Development, LLC
Not yet recruiting
ClinicalTrials.gov: Genetic_Disease | Recruiting, Not yet recruiting, Available Studies | United States | First posted in the last 100 days

March 15, 2019 / by / in